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MicroRNA-mRNA regulatory network study and apoptosis analysis on bone marrow endothelial cells induced by liver cirrhosis serum

机译:肝硬化血清所致骨髓内皮细胞的微小RNA-mRNA调控网络研究及凋亡分析

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摘要

Background and objective: As important components of bone marrow microenvironment, bone marrow endothelial cells (BMECs) have important roles in regulating haematopoietic functions of the bone marrow. In preliminary study, we found the humoral inhibitor in liver cirrhosis (LC) could lead to ultrastructure alterations of the bone marrow endothelium. The present study aimed to investigate functional changes occurred in BMECs during LC.
机译:背景与目的:骨髓内皮细胞(BMEC)作为骨髓微环境的重要组成部分,在调节骨髓的造血功能中具有重要作用。在初步研究中,我们发现肝硬化(LC)中的体液抑制剂可能导致骨髓内皮的超微结构改变。本研究旨在调查LC期间BMEC中发生的功能变化。

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