Spectroscopic studies and PM5 semiempirical calculations of tautomeric forms of gossypol Schiff base with (R)-tetrahydrofurfurylamine

摘要

A new Schiff base of gossypol with (R)-tetrahydrofurfurylamine (GSTF) was synthesised and its structure was studied by Fr-1R, H-1 NMR, C-13 NMR, N-15 NMR as well as PM5 semiempirical methods. It is shown that in the solution Schiff base exists in enamine-enamine tautomeric form. The structure of this tautomer is discussed in details. (C) 2004 Elsevier B.V. All rights reserved.