Mn(II), Co(II), Zn(II), Fe(III) and U (VI) complexes of 2-acetylpyridine ~4N-(2-pyridyl)thiosemicarbazone (HAPT); structural, spectroscopic and biological studies

摘要

The present work carried out a study on transition metal ion complexes which have been synthesizedfrom 2-acetylpyridine 4N-(2-pyridyl) thiosemicarbazone (HAPT) 1. These complexes namely[Zn(HAPT)C12] 2, [Mn (HAPT)C12] 3, [Co (HAPT)C12] 4, [Fe(APT)C12(H20)] 5 and [UO2(HAPT)(0Ac)216, werecharacterized by elemental analysis, spectral (IR, 1H NMR and UV-vis) and magnetic moment measure-ments. Thermal properties and decomposition kinetics of all compounds are investigated. The interpre-tation, mathematical analysis and evaluation of kinetic parameters (E, A, AH, AS and AG) of all thermaldecomposition stages have been evaluated using Coats-Redfern equation. The biochemical studiesshowed that, complexes 3 and 6 have powerful and complete degradation effect on the both DNA andprotein. The SOD-like activity exhibited that complex 3 has a strong antioxidative properties. The anti-bacterial screening demonstrated that, the free ligand (HAPT), complexes 2, 3 and 6 have the maximumand broad activities against Gram-positive and Gram-negative bacterial strains.