Cloning and analysis of the murine Foxi2 transcription factor

摘要

Forkhead transcription factors comprise a large family of key regulators of embryonic development. Here, we describe the cloning and analysis of the murine Foxi2 gene, coding for a putative 311 amino acid protein resembling Foxi subfamily members in mice and other species. Expression analysis during the final stages of embryonic development revealed that Foxi2 expression is mainly confined to subsets of cells in epithelial structures and particular ducts, in addition to the developing forebrain and neural retina. Since Fox1 factors are thought to be implicated in the regulation of cell fate, the highly restricted expression pattern of Foxi2 suggestive of a possible role in controlling cellular identity. (c) 2005 Elsevier B.V. All rights reserved.