The effects of anakinra on focal cerebral ischemic injury in rats

摘要

The inflammatory immune response plays an important role in the pathophysiological process of cerebral ischemic injury, especially during the enlargement of damage and the secondary damage after cerebral ischemia. There are high cytokine expression and proinflammatory infiltration in damage area after ischemic cerebral injury, which aggravates brain injury especially in reper-fusion period [1,2]. Interleukin-1beta (IL-1beta) is an inflammatory factor regulating the complex pathologic changes in acute ischemic brain injury. Increase in IL-1beta mRNA and protein level was observed after cerebral ischemia-reperfusion. IL-1beta plays an important role in inflammation of focal cerebral ischemia. IL-1beta contributes to brain tissue injury following cerebral ischemia-reperfusion [3,4].