Magnetic fluids as drug carrier in magnetically assisted chemotherapy - an experimental study

摘要

The present study is dedicated to the biomedical utilization of magnetic fluids. Drug delivery under magnetically control was the application studied experimentally by using two different magnetic fluids in combination with the same pharmaceutical molecule. The aqueous magnetic fluids were consistent with magnetite and maghemite nanoparticles coated with citric acid and respectively tetramethyl ammonium hydroxide while the rifampin molecule was taken as pharmaceutical principle used in lung disease treatment. Spectral measurements both in the visible (474 nm) and ultraviolet (334 nm) range were carried out to assess the drug delivery dynamics under magnetic control. The optimal ferrofluid dilution was established in the case of each ferrofluid - to about 66% -and the most convenient spectral band -the visible range one - when the rate of drug molecule releasing was the highest and best evidenced during the observation time of 48 hours. The basic protocol of the utilization of rifampin in combination with ferrofluids for targeted drug delivery in living tissues was shaped in the frame of this study.