System for fluorescence diagnosis and photodynamic therapy of cervical disease

摘要

This system is designed for development of fluorescence diagnosis and photodynamic therapy methods for cervical pathologies. Diagnosis is performed on the basis of multispectral autofluorescence images obtained using various types of excitation, as well as images in reflected white light after exposure to acetic acid. Said diagnosis is performed using an expert system for automatic recognition of cervical neoplasms; this expert system has been validated using verified images obtained from 151 patients. Based on test results, a sensitivity of 0.85-0.95 and specificity of 0.78-0.97 are obtained, depending on the scope of the differential diagnosis. It is shown that fluorescence images can be used to monitor photodynamic therapy. (C) 2016 Optical Society of America.