A pharmacokinetic evaluation of single and multiple doses of extended-release hydrocodone bitartrate in subjects experiencing surgical or osteoarthritic pain.

Cynthia Y Robinson; Christopher M Rubino; Stephen J Farr

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A pharmacokinetic evaluation of single and multiple doses of extended-release hydrocodone bitartrate in subjects experiencing surgical or osteoarthritic pain.

机译：在经历手术或骨关节炎疼痛的受试者中，单剂量和多次剂量的酒石酸氢可酮缓释药的药代动力学评估。

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摘要

The sustained plasma concentrations of hydrocodone support twice-daily dosing with a 12-hour dosing interval.

机译：氢可酮的持续血浆浓度支持每天两次，每次间隔12小时。

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《Journal of opioid management》 |2015年第5期|共11页
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Cynthia Y Robinson; Christopher M Rubino; Stephen J Farr;
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正文语种 eng
中图分类药学;
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1. A pharmacokinetic evaluation of single and multiple doses of extended-release hydrocodone bitartrate in subjects experiencing surgical or osteoarthritic pain. [J] . Cynthia Y Robinson, Christopher M Rubino, Stephen J Farr Journal of opioid management . 2015,第5期

机译：在经历手术或骨关节炎疼痛的受试者中，单剂量和多次剂量的酒石酸氢可酮缓释药的药代动力学评估。
2. Single- and Multiple-dose Pharmacokinetics of a Hydrocodone Bitartrate Extended-release Tablet Formulated With Abuse-deterrence Technology in Healthy, Naltrexone-blocked Volunteers [J] . Darwish Mona, Yang Ronghua, Tracewell William, Clinical therapeutics . 2015,第2期

机译：滥用抑制技术配制的酒石酸氢可酮酒石酸氢可酮缓释片在健康，纳曲酮阻滞的志愿者中的单剂量和多剂量药代动力学。
3. Comparison of single-dose and multiple-dose pharmacokinetics between two formulations of hydrocodone bitartrate/acetaminophen: immediate-release versus biphasic immediate- release/extended release [J] . Krishna Devarakonda, Kenneth Kostenbader, Michael J Giuliani, Journal of Pain Research . 2015,第2期

机译：酒石酸氢可酮/对乙酰氨基酚两种制剂单剂量和多剂量药代动力学的比较：即释与双相即释/延长释放
4. Dose Proportional Pharmacokinetics of a Methylphenidate Extended-Release Capsule Formulation [C] . Controlled Release Society annual meeting . 2004

机译：甲基酚盐延长释放胶囊配方的剂量比例药代动力学
5. Development and Validation of a Reverse-phase HPLC Method for the Assay of Hydrocodone Bitartrate, Chlorpheniramine Maleate, Methylparaben and Propylparaben in Extended-release Oral Suspension [D] . Anwiya, Riemon. 2018

机译：缓释口服混悬液中酒石酸氢可待酮，马来酸氯苯那敏，对羟基苯甲酸甲酯和对羟基苯甲酸丙酯的反相高效液相色谱法的建立和验证
6. Single- and multiple-dose pharmacokinetics of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) compared with immediate-release hydrocodone bitartrate/ibuprofen and immediate-release tramadol HCl/acetaminophen [O] . Krishna Devarakonda, Kenneth Kostenbader, Michael J Giuliani, 2015

机译：与速释氢可酮酒石酸氢盐/布洛芬和速释曲马多HCl /对乙酰氨基酚相比速释/缓释氢可酮酒石酸氢盐/对乙酰氨基酚双相的单剂量和多剂量药代动力学
7. Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) under fed and fasted conditions: two randomized open-label trials [O] . Krishna Devarakonda, Kenneth Kostenbader, Michael J. Giuliani, 2015

机译：在进食和禁食条件下2或3片双相立即释放/延长释放的氢可酮酒石酸氢盐/对乙酰氨基酚（MNK-155）的单剂量药代动力学：两项随机开放标签试验
8. Initial Submission: Pharmacokinetics of Tergitol 24-L-60N after a Single Dose in Rabbits in Rats: Species and Dose Route Comparisons with Cover Letter dated 09/24/1992 [R] . 1992

机译：初步提交：大鼠家兔单剂量后Tergitol 24-L-60N的药代动力学：物种和剂量路线与1992年9月24日的求职信比较

A pharmacokinetic evaluation of single and multiple doses of extended-release hydrocodone bitartrate in subjects experiencing surgical or osteoarthritic pain.

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