Psychological Treatments for Cognitive Dysfunction in Major Depressive Disorder: Current Evidence and Perspectives

摘要

Background: Patients with mood disorder, both unipolar and bipolar, present with significant cognitive dysfunction while unwell and this persists into euthymia. This impairment is to an extent independent of mood symptoms, has significant implications for prognosis, and exerts an effect on overall functioning. Neurobiological data suggest that the cognitive dysfunction may relate to underlying dysfunction of pre-frontal cortical areas of the brain and their connections with limbic structures.