Motor cortex stimulation and neuropathic pain: how does motor cortex stimulation affect pain-signaling pathways?

摘要

OBJECTIVE Neuropathic pain is often severe. Motor cortex stimulation (MCS) is used for alleviating neuropathic pain, but the mechanism of action is still unclear. This study aimed to understand the mechanism of action of MCS by investigating pain -signaling pathways, with the expectation that MCS would regulate both descending and ascending pathways.