An association analysis between 5-HTTLPR polymorphism and obsessive-compulsive disorder, Tourette syndrome in a Chinese Han population.

摘要

Obsessive-compulsive disorder (OCD) is a chronic and severe anxiety disorder presented with obsession and/or compulsion. With a lifetime prevalence of 1.9-3.3% [1], OCD negatively impacts many aspects of life. Tourette syndrome (TS) is a neurodevelop-mental disorder with an estimated prevalence of 1-10 persons per 1000 in school age children [2]. TS is a characterized by chronic involuntary motor tics, vocal tics in particular (DSM-IV, American Psychiatric Association, 1994). OCD and TS are distinct entities, but share common features of repetitive behaviors with a juvenile onset. A number of candidate genes of dopamine and serotonin system have been studied in OCD and in TS [3,4], Particular emphasis has been placed on functional variants in the serotonin transporter gene in the past few years.