Immune Responses of Chicken Immunized with Marek's Disease Vaccines

摘要

The experiment was conducted to study the dynamic changes of immune responses of chicks immunized with Marck's disease (MD) trivalcnt vaccine and turkey hcrpcsvirus (HVT) at one day age. Results were found that after immunization of chicks with MD vaccines, the interlcukinc— 2 (IL-2) inductive activity and IL-2 receptor expression of T cells from thymus and spleen significantly increased, suggesting that the immunorcgulativc function was markedly enhanced in the immune organs; the number of antibody—producing cells, the number and prolifcrative function of T cells rose markedly in Bursa Fabricius, spleen and thymus, indicating that the cellular and humoral immune rcspbnses were elevated rcmarkablly in the central and peripheral immune organs; thenumber of T and antibody—producing cells as well as the content of IgG, IgA and IgM obviously mounted in cccal tonsil, Harder ian gland mucosal lymphoid tissues of bronchus along with tears, trachea washings, bile and intestinal fluids, demonstrating that the local and mucosal immunity was raised in the respiratory and digestive tract; the levels of immune responses mentioned above in the trivalcnt vaccine—immuniacd chicks were apparently higher than those of HVT—immunized birds.