~(99)Mo/~(99m)Tc_~(113)Sn/~(113m)In Dual Radioisotope Generator Based on 6-Tungstocerate(IV) Column Matrix

摘要

Elutions of~(99m)Tc and~(113m)In have been performed subsequently with 10 mL of 0.9% NaCl solution and 10 mL of 0.1 M HC1 solution, respectively, from 6-tungstocerate(IV) chromatographic column loaded with 0.54 MBq~(99)Mo and 0.45 MBq~(113)Sn, using alumina-column filter in the case of~(99m)Tc. Radionuclidic purity of both eluates was 99.99%. Elution yields of 72.5±5.8% and 62.2±3.7%, and radiochemical purities of 96.9±1.0% (as~(99m)TcO_4~-) and 88.4±2.5% (as~(113m)In~(3+)) have been obtained for~(99m)Tc and~(113m)In, respectively. Al and W impurities in the~(99m)Tc and ~(113m)In eluates, respectively, were found to be within the accepted limits, whereas no Ce impurities were detected in both eluates. Also trials have been carried out on a similar system to obtain mixed~(99m)Tc-~(113m)In eluates from 6- tungstocerate column with different~(99m)Tc/~(113m)In ratios using 0.9% NaCI–HC1 eluents of different pH values. To separate~(99m)Tc and~(113m)In from each other, these mixed eluates were passed through a column of hydrous zirconium oxide which was then eluted with 10 mL of 0.9% NaCl solution and 15 mL of 0.1 M HC1 solution, respectively. No W, Ce, or Zr impurities were detected in the ~(99m)Tc and~(113m)In eluates obtained in these trials.