Vanillic Acid Derivatives from the Green Algae Cladophora socialis As Potent Protein Tyrosine Phosphatase 1B Inhibitors

摘要

A novel vanillic acid derivative (1) and its sulfate adduct (2) were isolated from a green algae,Cladophora socialis.The structures of 1 and 2 were elucidated from NMR and HRESIMS experiments.Both compounds showed potent inhibitory activity against protein tyrosine phosphatase 1B (PTP1B),an enzyme involved in the regulation of insulin cell signaling.Compounds 1 and 2 had IC50 values of 3.7 and 1.7 mu M,respectively.