Sesquiterpenes from Thapsia nitida var.meridionalis and Thapsia nitida var.nitida

摘要

Nine new eudesmanolides(1-9),two new guaianolides(12 and 13),and a new germacrane(10),along with a previously reported guaianolide(11),have been isolated from the roots of Thapsia nitida var.meridionalis.Thapsia nitida var.nitida also afforded compound 13 along with a new guaianolide(14).The structure of 13 was confirmed by X-ray crystallographic analysis.Compounds 1,2,and 11-14 have been tested as potential inhibitors of the sarco-and endoplasmic Ca~(2+)-dependent ATPases(SERCA)pump.None of them showed significant activities.