ent-Labdane Diterpenoids from Andrographis paniculata

摘要

Six new ent-labdane diterpenoids,3-O-beta-D-glucopyranosyl-14,19-dideoxyandrographolide (1),14-deoxy-17-hydroxy-andrographolide (2),19-O-[beta-D-apiofuranosyl(l->2)-beta-D-glucopyranoyl]-3,14-dideoxyandrographolide (3),3-O-beta-D-glucopyranosylandrographolide (4),125-hydroxyandrographolide (5),and andrographatoside (6),together with 17 known analogues,were isolated from the aerial parts of Andrographis paniculata.The structures of 1-6 were determined by spectroscopic data analysis.All compounds isolated were evaluated for their inhibitory activity against several bacterial and fungal strains.