School of Pharmacy,Kaohsiung Medical University,Kaohsiung 807,Taiwan,Department of Forest Resource,Management and Technology,National Pingtung University of Science and Technology,Ping-Tung 912,Taiwan,and Department of Microbiology and Immunology,Nat

摘要

In an effort to explore the contribution of the sugar constituents of pharmaceutically relevant glycosylated natural products,chemists have developed glycosylation methods that are amenable to the generation of libraries of analogues with a broad array of glycosidic attachments.Recently,two complementary glycorandomization strategies have been described,namely,neoglycorandomization,a chemical approach based on a one-step sugar ligation reaction that does not require any prior sugar protection or activation,and chemoenzymatic glycorandomization,a biocatalytic approach that relies on the substrate promiscuity of enzymes to activate and attach sugars to natural products.Since both methods require reducing sugars,this review first highlights recent advances in monosaccharide generation and then follows with an overview of recent progress in the development of neoglycorandomization and chemoenzymatic glycorandomization.