Discovery of New Natural Products by Application of X-hitting,a Novel Algorithm for Automated Comparison of Full UV Spectra,Combined with Structural Determination by NMR Spectroscopy

摘要

X-hitting,a.newly developed algorithm for automated comparison of UV data,has been used for the tracking of two novel spiro-quinazoline metabolites,lapatins A (1) and B (2),in a screening study targeting quinazolines.The structures of 1 and 2 were elucidated by analysis of spectroscopic data,primarily 2D NMR.