Anti-AIDS agents. 48. Anti-HIV activity of moronic acid derivatives andthe new melliferone-related triterpenoid isolated from Brazilian propolis

Ito J; Chang FR; Wang HK; Park YK; Ikegaki M; Kilgore N; Lee KH

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Anti-AIDS agents. 48. Anti-HIV activity of moronic acid derivatives andthe new melliferone-related triterpenoid isolated from Brazilian propolis

机译：抗艾滋病剂。 48.从巴西蜂胶中分离出的巴豆酸衍生物和新的与蜜丽酮相关的三萜类化合物的抗艾滋病毒活性

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A new triterpenoid named melliferone (1), three known triterpenoids, moronic acid (2), anwuweizonic acid (3), and betulonic acid (4), and four known aromatic compounds (5-8) were isolated from Brazilian propolis and tested for anti-HIV activity in H9 lymphocytes. Moronic acid (2) showed significant anti-HIV activity (EC50 <0.1 mug/mL, TI > 186) and was modified to develop more potent anti-AIDS agents.

机译：从巴西蜂胶中分离出一种新的三萜类化合物，命名为melliferone（1），三种已知的三萜类化合物，吗啉酸（2），anwuweizonic酸（3）和betulonic酸（4）以及四种已知的芳香族化合物（5-8），并进行了含量测定。 H9淋巴细胞中的抗HIV活性。 Moronic acid（2）表现出显着的抗HIV活性（EC50 <0.1杯/毫升，TI> 186），经过修饰可开发出更有效的抗艾滋病药物。

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《Journal of natural products》 |2001年第10期|共4页
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Ito J; Chang FR; Wang HK; Park YK; Ikegaki M; Kilgore N; Lee KH;
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正文语种 eng
中图分类中药学;生药学（天然药物学）;
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1. Anti-AIDS agents. 48. Anti-HIV activity of moronic acid derivatives andthe new melliferone-related triterpenoid isolated from Brazilian propolis [J] . Ito J, Chang FR, Wang HK, Journal of natural products . 2001,第10期

机译：抗艾滋病剂。 48.从巴西蜂胶中分离出的巴豆酸衍生物和新的与蜜丽酮相关的三萜类化合物的抗艾滋病毒活性
2. Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents [J] . Yu DL, Sakurai Y, Chen CH, Journal of Medicinal Chemistry . 2006,第18期

机译：抗艾滋病药69.醛酸和其他三萜衍生物作为新型有效的抗艾滋病药
3. Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives. [J] . Ishida J, Wang HK, Oyama M, Journal of natural products . 2001,第7期

机译：抗艾滋病剂。 46.哈曼（Hyman）的抗HIV活性，这是塞舌草（Symplocos setchuensis）的抗HIV原理及其衍生物。
4. Anti-HIV activity of natural triterpenoids and hemisynthetic derivatives 2004-2009 [C] . Bruce K. Cassels, Marcelo Asencio Phytochemical Society of Europe Meeting . 2011

机译：2004-2009的天然三萜类固定剂和半同仁衍生物的抗HIV活性
5. DDB and betulinic acid-derivatives as potent chemosensitizing, chemopreventive, and anti-HIV agents. [D] . Hung, Hsin-Yi. 2012

机译：DDB和桦木酸衍生物作为有效的化学增敏剂，化学预防剂和抗HIV剂。
6. Anti-AIDS Agents 69. Moronic Acid and Other Triterpene Derivatives as Novel Potent Anti-HIV Agents [O] . Donglei Yu, Yojiro Sakurai, Chin-Ho Chen, -1

机译：抗艾滋病毒药物69.醛糖酸和其他三萜衍生物作为新型抗艾滋病毒有效药物
7. Structure-activity relationship study of pyrimido1,2-c1,3benzothiazin-6-imine derivatives for potent anti-HIV agents. [O] . Mizuhara Tsukasa, Oishi Shinya, Ohno Hiroaki, 2012

机译：嘧啶1,2-c 1,3苯并噻嗪-6-亚胺衍生物作为抗HIV有效剂的构效关系研究。

Anti-AIDS agents. 48. Anti-HIV activity of moronic acid derivatives andthe new melliferone-related triterpenoid isolated from Brazilian propolis

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