Bacillusin A, an Antibacterial Macrodiolide from Bacillus amyloliquefaciens AP183

摘要

Bioassay-guided fractionation of the organic extracts of a Bacillus amyloliquefaciens strain (AP183) led to the discovery of a new macrocyclic polyene antibiotic, bacillusin A (1). Its Structure Was assigned by interpretation of NMR and MS spectroscopic data as a novel macrodiolide Composed of dimeric 4-hydroxy-2-methoxy-6-alkenylbenzoic acid lactones with conjugated pentaene-hexahydroxy polyketide,chains. Compound 1 showed potent antibacterial activities against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium with minimum inhibitory concentrations in a range of 0.6 to 1.2 mu g/mL. The biosynthetic significance of this unique class of antibiotic compounds is briefly discussed.