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首页> 外文期刊>Journal of neurointerventional surgery >Percutaneous sclerotherapy with ethanolamine oleate for lymphatic malformations of the head and neck
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Percutaneous sclerotherapy with ethanolamine oleate for lymphatic malformations of the head and neck

机译:乙醇胺油酸酯经皮硬化疗法治疗头颈部淋巴畸形

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摘要

Introduction: Lymphatic malformations are low flow congenital lesions that frequently occur in the head and neck, and often require treatment. Multiple therapeutic modalities exist, including percutaneous sclerotherapy, which has been performed successfully with numerous sclerosants. Few data exist on use of ethanolamine oleate to treat lymphatic malformations. This study reports single center results using this agent to treat lymphatic malformations of the head and neck. Materials and methods: Prospectively maintained procedural records were retrospectively reviewed to identify all patients with lymphatic malformations who underwent percutaneous sclerotherapy. The Mulliken and Glowacki classification was used to diagnose lymphatic malformations. Medical records and images were reviewed to record demographic information, lesion characteristics, treatment sessions, and clinical and imaging response. Lesions and outcomes were evaluated with both qualitative and quantitative volumetric analysis. Response was assessed after each session and after all sessions in those patients undergoing more than one intervention, and χ2analysis was performed to evaluate the effects of lesion and demographic characteristics on outcomes. Results: 12 interventions were performed for lesions in 10 patients. No procedural complications occurred following any procedures. Four (40.0%) patients had an excellent result after treatment, which was accomplished in one session for each of these lesions. Four (40.0%) had good results. One (10.0%) had a fair result after three sessions. One (10.0%) patient with an indeterminate syndrome with multiple congenital anomalies had a poor response following treatment. The family decided to withdraw care, and the airway was compromised. Average lesion volume reduction was 28% for all lesions and 42% when excluding the lesion for which future treatments were declined. Purely macrocystic lesions were more likely to have an excellent response to treatment than lesions with both macrocystic and microcystic components. Conclusions: Percutaneous sclerotherapy using ethanolamine oleate to treat lymphatic malformations of the head and neck appears safe and efficacious. This agent should be considered when treating these complex lesions, particularly those that are exclusively macrocystic. Further investigation of such treatments should evaluate this agent alongside the many others currently utilized.
机译:简介:淋巴畸形是低流量的先天性病变,常发生在头部和颈部,通常需要治疗。存在多种治疗方式,包括经皮硬化疗法,已成功地使用多种硬化剂进行了治疗。关于使用乙醇胺油酸酯治疗淋巴畸形的资料很少。这项研究报告了使用该药物治疗头颈部淋巴畸形的单中心结果。材料和方法:回顾性地回顾了前瞻性保存的程序记录,以鉴定所有经皮硬化治疗的淋巴畸形患者。 Mulliken和Glowacki分类用于诊断淋巴畸形。审查病历和图像,以记录人口统计信息,病变特征,治疗时间以及临床和影像学反应。通过定性和定量体积分析评估病变和结局。在接受一次以上干预的那些患者中,在每个疗程后和所有疗程后评估反应,并进行χ2分析以评估病变和人口统计学特征对结局的影响。结果:对10例患者的病变进行了12次干预。任何程序均未发生程序并发症。四名(40.0%)患者在治疗后取得了优异的效果,这些病变中的每一个均在一个疗程中完成。有四个(40.0%)的结果很好。 3个疗程后有1个(10.0%)的结果令人满意。一例(10.0%)患有多种先天性异常的不确定综合征患者在治疗后反应较差。家庭决定撤回护理,呼吸道受到损害。所有病灶的平均病灶体积减少为28%,如果不包括未来治疗方法下降的病灶,则平均病灶体积减少为42%。与具有大囊性和微囊性成分的病变相比,纯大囊性病变更有可能对治疗产生出色的反应。结论:乙醇胺油酸酯经皮硬化疗法治疗头颈部淋巴畸形显得安全有效。在治疗这些复杂的病变,特别是那些仅是大囊性病变时,应考虑使用这种药物。对此类治疗方法的进一步研究应与目前使用的许多其他药物一起评估该药物。

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