Osteoporosis model

摘要

We read the paper by Lee and colleagues2 (Lee CY, Chan SH, Lai HY, et al: A method to develop an in vitro osteoporosis model of porcine vertebrae: histological and biomechanical study. Laboratory investigation. J Neurosurg Spine 74:789-798, June 2011) with a great interest. The authors presented an in vitro model for porcine osteoporotic vertebrae in their article. They indicated that their model is that of an "osteoporotic" vertebra; however, we do not agree with their characterization. The vertebrae created with the proposed method are not "osteoporotic" vertebrae but, rather, are demineralized vertebrae. In order to truly mimic osteoporosis, the collagen content, and in fact the structure of the trabeculae itself, would require removal. In the authors' model, unlike osteoporosis, the structure of the trabeculae remains after decalcification