A strategy for effective radioprotection by chitosan-based long-circulating nanocarriers

摘要

We demonstrate a strategy for effective radioprotection by chitosan-based long-circulating nanocarriers with radio-protective agents. The stable encapsulation does not restrain its radioprotective capability, and exhibits prolonged retention time in blood with a half-life of similar to 10 h, thereby showing more beneficial effects than the pure agent in therapeutic efficacy for irradiated mice.