Late complications from chemoradiotherapy for cervical cancer: reflections from cervical cancer survivors 10 years after the national cancer institute alert.

摘要

Around 10 years ago, the US National Cancer Institute issued an unprecedented clinical alert stating that chemo-radiotherapy should be considered for women with cervical cancer instead of radiotherapy alone [1]. This was based on the results of five randomised trials, each of which showed a benefit of chemoradiotherapy on survival. Since that recommendation, cisplatin-based chemoradiotherapy has become the standard of care in many countries for women with high-risk early stage and locally advanced cervical cancer. However, a number of important questions remained and there were concerns among the clinical community regarding the late effects of chemoradiotherapy, which anecdotally seemed to be worse than with radiotherapy alone [2].