Synthesis of chiral oxazolidinone derivatives through lipase-catalyzed kinetic resolution

摘要

The synthesis of enantioenriched oxazolidinone derivatives through lipase-catalyzed kinetic resolution is described. The synthesis comprised a two-step, cascade acylation in one pot, resulting in a range of oxazolidinone derivatives in good yields and excellent enantiopurities. (C) 2015 Elsevier B.V. All rights reserved.