Trastuzumab-induced radiation recall dermatitis--first reported case.

摘要

We would like to report the first case to our knowledge of radiation recall dermatitis (RRD) triggered by trastuzumab (Herceptin®). A 71-year-old woman with previous left mastectomy for ductal carcinoma in situ presented with distortion of her right breast in February 2008. Ultrasound-guided core biopsy confirmed invasive ductal carcinoma. She underwent right-sided mastectomy and axillary nodal dissection. Histopathology confirmed multifo-cal invasive breast cancer. Two tumours were identified: a grade 111, 35 mm, oestrogen receptor-positive, progesterone receptor-negative, Her2-positive invasive ductal cancer and a grade II, 35 mm, oestrogen receptor-positive, progesterone receptor-positive, Her2-negative, invasive lobular cancer. The ductal carcinoma was Her-2 (Herceptest) 2+ and fluorescence in situ hybridisation amplified. Four lymph nodes were positive for cancer out of 14 nodes examined.