Investigation of ionic liquids as reaction media for enzymatic enantioselective acylation of amines

摘要

The use of ionic liquids as reaction media for lipase-catalyzed enantioselective acylation of l-phenylethylumine (1) and 2-phenyl-l-propylamine (2) with 4-pentenoic acid was investigated.The best performing ionic liquid for each of these amines as well as its solvent properties were very different.Preparative scale kinetic resolution of 1 was performed efliciently in l-butyl-2.3-dimcihy]imidazolium triflu-oromethanesulphonate.