The IMPORT trials are launched (September 2006).

摘要

Breast radiotherapy reduces breast cancer recurrence and overall mortality in women with early breast cancer treated by tumour excision. However, radiation volume and dose are only crudely adjusted to risks of local relapse and Long-term complications. Women with screen-detected lesions are asked to accept the same complication rate as those with higher risk disease in exchange for much less benefit. Moves to adapt radiotherapy dose intensity more closely to risk of relapse have been hampered by, among other things, poor localisation of the volume at highest relapse risk viz. the tumour bed. Internal fiducial markers, X-ray computer tomography, intensity modulated conformal radiotherapy and image-guided radiotherapy ought to mean that partial (boost) breast volumes are localised and treated with greater accuracy and better outcomes. The better outcomes include elimination of cardiac exposure and less scattered radiation to internal organs as well as less injury to the breast, ribcage and lung.