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Locally advanced pancreatic cancer: The role of definitive chemoradiotherapy

机译:局部晚期胰腺癌:确定性放化疗的作用

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At the time of diagnosis, around 20% of patients with pancreatic cancer present at a resectable stage, 50% have metastatic disease and 30% have locally advanced tumour, non-metastatic but unresectable because of superior mesenteric artery or coeliac encasement. Despite advances in chemoradiotherapy and improved systemic chemotherapeutic agents, patients with locally advanced pancreatic cancer suffer from high rates of distant metastatic failure and from local progression, with a median survival time ranging from 5 to 11 months. In the past 30 years, modest improvements in median survival have been attained for these patients treated by chemoradiotherapy or chemotherapy protocols. The optimal therapy for patients with locally advanced pancreatic carcinoma remains controversial. This review aims to evaluate the role of radiotherapy for these patients.
机译:在诊断时,约有20%的胰腺癌患者处于可切除的阶段,其中50%患有转移性疾病,而30%的患者由于肠系膜上动脉或腹腔的包裹而转移了局部肿瘤,无转移但无法切除。尽管放化疗的进展和全身化疗药物的改进,局部晚期胰腺癌患者仍存在较高的远处转移失败率和局部进展,中位生存时间为5至11个月。在过去的30年中,通过放化疗或化疗方案治疗的这些患者的中位生存期已获得适度的改善。对于局部晚期胰腺癌患者的最佳治疗仍存在争议。这篇综述旨在评估放疗对这些患者的作用。

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