Optimising stereotactic body radiotherapy for non-small cell lung cancer with volumetric intensity-modulated arc therapy-a planning study

摘要

Aims:The potential advantages of stereotactic body radiotherapy (SBRT) for early stage non-small cell lung cancer (NSCLC) over conventional fractionated radiotherapy include a higher biological effective dose, a reduction in accelerated repopulation, greater patient convenience and reduced demand on radiotherapy resources. Before introducing SBRT in our department, a review of planning and delivery was undertaken, starting with an assessment of optimum beam number and arrangement. Materials and methods: Radiotherapy planning computed tomography scans for five patients previously treated for T1 peripheral NSCLC were selected. In each the contoured tumour had planning target volume (PTV) margins of 1cm in all directions. Forward-planned three-field coplanar and non-coplanar plans and a seven-field coplanar plan were produced and optimised. In-house inverse-planning software (AutoBeam) was used to generate three-, five-, seven- and nine-field coplanar and non-coplanar plans and two volumetric intensity-modulated arc therapy (VMAT) plans. The resulting V 20, V 11, PTV 90, PTV 95 and mean lung dose were compared. Results: Analysis of variance showed non-coplanar plans to have lower V 11 and higher PTV 90 and PTV 95 than coplanar plans. VMAT showed equivalent V 20 and target coverage when compared with the best non-coplanar plans, but with a faster delivery time (2min 8s versus 12min 40s). Conclusions: Inverse-planned five-field non-coplanar plans and VMAT improve target coverage while minimising the higher dose to normal lung tissue for SBRT of NSCLC compared with coplanar beam arrangements. VMAT is preferable because of significantly shorter treatment delivery times.