Rapid recurrence of craniopharyngioma following recombinant human growth hormone replacement.

摘要

A 10-year-old boy was referred because of postoperative growth hormone deficiency (GHD) that occurred 5 years after initial complete resection of craniopharyngioma (CP). On admission, basal GH was 0.10 ng/ml and peak GH was 0.21 ng/ml after GH-releasing hormone plus arginine, which met the criteria for GHD. No residual changes were recognized on MRI scans obtained in 2007 (Fig. 1, middle panel), and we commenced recombinant human growth hormone (rhGH, somatotropin, 0.025 mg/kg/day) therapy. After 17 months of rhGH therapy, MRI scans revealed a large cystic mass in the suprasellar region (Fig. 1, right panel). The tumor was removed and diagnosed histologi-cally as a CP, as before.