Denbinobin upregulates miR-146a expression and attenuates IL-1 |3-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes

Chia-Ron Yang; Kao-Shang Shih; Jing-Ping Liou

首页> 外文期刊>Journal of molecular medicine: Official organ of the "Gesellschaft Deutscher Naturforscher und Arzte." >Denbinobin upregulates miR-146a expression and attenuates IL-1 |3-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes

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Denbinobin upregulates miR-146a expression and attenuates IL-1 |3-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes

机译：Denbinobin上调miR-146a表达并减弱IL-1 | 3诱导的骨关节炎成纤维细胞样滑膜细胞ICAM-1和VCAM-1表达上调。

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Interleukin-lp (IL-1 (3) upregulates intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) expressions in osteoarthritis fibroblast-like synoviocytes (OA-FLS) via nuclear factor (NF)-KB-mediated mechanism; enhancement of leukocyte infiltration and upregulation of proinflammatory mediators play a crucial role in OA pathophysiology.

机译：白介素-lp（IL-1（3）通过核因子（NF）上调骨关节炎成纤维样滑膜细胞（OA-FLS）中的细胞间粘附分子1（ICAM-1）和血管细胞粘附分子1（VCAM-1）的表达）-KB介导的机制;白细胞浸润的增强和促炎介质的上调在OA病理生理中起着至关重要的作用。

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《Journal of molecular medicine: Official organ of the "Gesellschaft Deutscher Naturforscher und Arzte."》 |2014年第11期|共12页
作者
Chia-Ron Yang; Kao-Shang Shih; Jing-Ping Liou;
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正文语种 eng
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1. Denbinobin upregulates miR-146a expression and attenuates IL-1 |3-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes [J] . Chia-Ron Yang, Kao-Shang Shih, Jing-Ping Liou Journal of molecular medicine: Official organ of the "Gesellschaft Deutscher Naturforscher und Arzte." . 2014,第11期

机译：Denbinobin上调miR-146a表达并减弱IL-1 | 3诱导的骨关节炎成纤维细胞样滑膜细胞ICAM-1和VCAM-1表达上调。
2. Upregulated expression of CCR3 in osteoarthritis and CCR3 mediated activation of fibroblast-like synoviocytes [J] . Chang Xin, Shen Jirong, Yang Haiwei, Cytokine . 2016,第1期

机译：CCR3在骨关节炎中的表达上调和CCR3介导的成纤维样滑膜细胞激活
3. NF-kappa B regulates VCAM-1 expression on fibroblast-like synoviocytes. [J] . Li P, Sanz I, OKeefe RJ, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2000,第11期

机译：NF-κB调节成纤维样滑膜细胞上VCAM-1的表达。
4. Hyaluronan promotes IL-10 expression in fibroblast-like synoviocytes from patients with tibia plateau fracture [C] . Teng-Le Huang, Horng-Chaung Hsu, Feng-Huei Lin, IEEE Annual Northeast Bioengineering Conference . 2009

机译：透明质酸可促进胫骨平台骨折患者成纤维样滑膜细胞中IL-10的表达
5. Expression and regulation of ICAM-1 and VCAM-1 in streptococcal-cell-wall-induced hepatic granuloma [D] . Xie, Lei. 1996

机译：ICAM-1和VCAM-1在链球菌细胞壁诱导的肝肉芽肿中的表达和调控
6. GM-CSF IL-1 alpha IL-1 beta IL-6 IL-8 IL-10 ICAM-1 and VCAM-1 gene expression and cytokine production in human duodenal fibroblasts stimulated with lipopolysaccharide IL-1 alpha and TNF-alpha. [O] . G Pang, L Couch, R Batey, 1994

机译：脂多糖IL-1α刺激人十二指肠成纤维细胞中GM-CSFIL-1αIL-1βIL-6IL-8IL-10ICAM-1和VCAM-1基因表达和细胞因子产生和TNF-α。
7. Inhibition of Carrageenan/Kaolin-Induced Arthritis in Rats and of Inflammatory Cytokine Expressions in Human IL-1β-Stimulated Fibroblast-like Synoviocytes by a Benzylideneacetophenone Derivative [O] . Bongjun Sur, Seungmin Kang, Mijin Kim, 2018

机译：通过苄基苯酮衍生物抑制大鼠大鼠大鼠和炎症细胞因子的炎症性关节炎和炎症细胞因子的炎症性关节炎

Denbinobin upregulates miR-146a expression and attenuates IL-1 |3-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes

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