Histomorphometric analysis of extraction sockets augmented with Bio-Oss Collagen after a 6-week healing period: a prospective study.

摘要

For a predictable esthetic outcome of implant-retained restoration after tooth removal, the biology of the healing of extraction sockets needs to be considered (Quirynen et al. 2007). Based on a number of studies including human and animal experiments, it is known that there are a series of events involved in the process of healing, such as: (1) formation and maturation of blood clot, (2) infiltration of immature mesenchymal cells, and (3) establishment of a provisional matrix from which bone formation results (Amler 1969; Cardaropoli et al. 2003; Araujo &. Lindhe 2005). The various stages of the process of healing in mandibular extraction sockets of canines show an initial phase with a boost of bone formation within the first 30 days and a subsequent resorption of this newly formed bone to about 15% of the initial amount and gradual replacement by the bone marrow (Cardaropoli et al. 2003). After the removal of teeth, ridge alterations in width and height occur based on resorp-tive processes of the newly formed bone within the socket and also of the original bone in canine models (Cardaropoli et al. 2003; Araujo &. Lindhe 2005) and humans (Atwood 1963; Winkler 2002; Schropp et al. 2003b).