首页> 外文期刊>The Tohoku Journal of Experimental Medicine >Analysis of plasma nitriteitrate in human thermal injury.
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Analysis of plasma nitriteitrate in human thermal injury.

机译:人体热损伤中血浆亚硝酸盐/硝酸盐的分析。

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The aim of this study is to examine the characteristics of nitriteitrate (NOx), the final metabolite of nitric oxides, in plasma after burn injury. A total of 83 blood samples were collected from 19 patients on arrival, day 1, day 3, and day 5 after suffering burn injuries and from 7 non-burned volunteers. We measured the NOx levels in plasma using the Griess method, and analyzed the relationships among plasma the NOx levels, the burn-magnitude, and the blood examination data using a stepwise multivariate regression analysis. The plasma NOx levels at hospital-arrival after burns significantly exceeded those of non-burned volunteers, and the NOx levels in the plasma returned to normal range after day 1. Based on the findings of a multivariate analysis, the plasma NOx levels at admission to the hospital were not found to be related to the total burn surface area, the burn index or inhalation injury, but they were significantly related to age. Furthermore, these plasma NOx levels were also related to the platelet count, neutrophil count and blood urea nitrogen. The increase in the plasma NOx level may therefore play an important role in the pathophysiology of elderly burned patients, while the nitric oxide levels in the plasma might also play a role in inhibiting the constriction of microvascular smooth muscle in extensively burned patients.
机译:这项研究的目的是检查烧伤后血浆中亚硝酸盐/硝酸盐(NOx)的最终代谢产物的特征。在烧伤后的第1天,第3天和第5天到达的19位患者和7位未烧伤的志愿者中共采集了83份血样。我们使用Griess方法测量了血浆中的NOx水平,并使用逐步多元回归分析法分析了血浆中NOx水平,燃烧幅度和血液检查数据之间的关系。烧伤后到达医院的血浆NOx水平大大超过未烧伤志愿者的血浆NOx水平,并且血浆NOx水平在第1天后恢复到正常范围。根据多变量分析的结果,入院时血浆NOx水平医院与烧伤总面积,烧伤指数或吸入损伤无关,但与年龄显着相关。此外,这些血浆NOx水平也与血小板计数,中性粒细胞计数和血尿素氮有关。因此,血浆NOx水平的升高可能在老年烧伤患者的病理生理中起重要作用,而血浆中的一氧化氮水平也可能在广泛烧伤患者中抑制微血管平滑肌的收缩。

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