Whole structure-activity relationships of the fat-accumulation inhibitor (-)-ternatin: Recognition of the importance of each amino acid residue

摘要

A series of Ala and Aoc analogues of (-)-ternatin were prepared, and their bioactivities were assessed by a fat-accumulation inhibition assay using 3T3-L1 adipocytes, which led to the discovery of key structure-activity relationships (SAR).