Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution

Todd AK; Adams A; Thorpe JH; Denny WA; Wakelin LP; Cardin CJ

首页> 外文期刊>Journal of Medicinal Chemistry >Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution

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Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution

机译：主要的沟槽结合和“ DNA诱导”适合将混合的拓扑异构酶I / II毒物N-（2-（2-（二甲氨基）乙基）ac啶-4-羧酰胺（DACA）的衍生物插入DNA：复合的X射线结构至1.3-A分辨率的d（CG（5-BrU）ACG）2

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来源
《Journal of Medicinal Chemistry》 |1999年第4期|共5页
作者
Todd AK; Adams A; Thorpe JH; Denny WA; Wakelin LP; Cardin CJ;
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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Acridines; Antineoplastic Agents; DNA Topoisomerase; DNA Topoisomerase ATP Hydrolysing chemistry; 吖啶类; 抗肿瘤药; DNA拓扑异构酶; 嵌入剂;

机译：Acridines;Antineoplastic Agents;DNA Topoisomerase;DNA Topoisomerase ATP Hydrolysing chemistry;吖啶类;抗肿瘤药;DNA拓扑异构酶;嵌入剂;

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1. Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution [J] . Todd AK, Adams A, Thorpe JH, Journal of Medicinal Chemistry . 1999,第4期

机译：主要的沟槽结合和“ DNA诱导”适合将混合的拓扑异构酶I / II毒物N-（2-（2-（二甲氨基）乙基）ac啶-4-羧酰胺（DACA）的衍生物插入DNA：复合的X射线结构至1.3-A分辨率的d（CG（5-BrU）ACG）2
2. Extravascular Transport of the DNA Intercalator and Topoisomerase Poison N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA): Diffusion and Metabolism in Multicellular Layers of Tumor Cells [J] . Kevin O.Hicks, Frederik B.Pruijn, BVruce C.Baguley, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2001,第3期

机译：DNA嵌入剂和拓扑异构酶毒N- [2-（二甲基氨基）乙基] ac啶-4-羧酰胺（DACA）的血管外运输：肿瘤细胞多细胞层中的扩散和代谢。
3. Crystal structure of the topoisomerase II poison 9-amino-(N-(2-dimethylamino)ethyl)acridine-4-carboxamide bound to the DNA hexanucleotide d(CGTACG)2. [J] . Adams A, Guss JM, Collyer CA, Biochemistry . 1999,第29期

机译：拓扑异构酶II的晶体结构与DNA六核苷酸d（CGTACG）2结合的9-氨基-（N-（2-二甲基氨基）乙基）ac啶-4-甲酰胺具有毒性。
4. Conformation of B-DNA containing O6-ethyl-G-C base pairs stabilized by minor groove binding drugs: molecular structure of d(CGCe6GAATTCGCG complexed with Hoechst 33258 or Hoechst 33342. [O] . M Sriram, G A van der Marel, H L Roelen, 1992

机译：通过小沟结合药物稳定的含有O6-乙基-G-C碱基对的B-DNA的构象：与Hoechst 33258或Hoechst 33342络合的d（CGC e6G AATTCGCG的分子结构。

Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-A resolution

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