Inhibition of acetyleholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: A promising direction for the multi-target-directed ligands gold rush

摘要

Alzheimer's disease (AD) is a multifactorial syndrome with several target proteins contributing to its etiology. To confront AD, an innovative strategy is to design single chemical entities able to simultaneously modulate more than one target. Here, we present compounds that inhibit acety1cholinesterase and NMDA receptor activity. Furthermore, these compounds inhibit AChE-induced AP aggregation and display antioxidant properties, emerging as lead candidates for treating AD.