New Cannabidiol Derivatives:Synthesis,Binding to Cannabinoid Receptor,and Evaluation of Their Antiinflammatory Activity

摘要

Cannabidiol(CBD)and cannabidiol dimethyl hephtyl(CBD-DMH)were hydrogenated to give four different epimers.The new derivatives were evaluated for their ability to modulate the production of reactive oxygen intermediates(ROI),nitric oxide(NO),and tumor necrosis factor(TNF-alpha)by murine macrophages,and for their binding to the cannabinoid receptor(CB_1).Surprisingly,we found that these derivatives exhibit good binding to CB_1.In addition hydrogenated CBD and CBD-DMH demonstrate bioactivities different from their original compounds.