iV,iV'-Bisbenzylidenebenzene-l,4-diamines and N,N-Bisbenzylidenenaphthalene-l,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors

摘要

A series of N,N'-bisbenzylidenebenzene-l,4-diamine and N,N'-bisbenzylidenenaphthalene-l,4-diamine derivatives were synthesized as inhibitors for human sirtuin type 2 (SIRT2).The design of the new compounds was based on two earlier reported hits from molecular modeling and virtual screening.The most potent compound was N,N'-bis(2-hydroxybenzylidene)benzene-l,4-diamine,which was equipotent with the most potent hit compound and well-known SIRT2 inhibitor sirtinol.