A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

Wolfe MS; Citron M; Diehl TS; Xia W; Donkor IO; Selkoe DJ

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A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

机译：基于底物的二氟酮选择性抑制阿尔茨海默氏病的γ-分泌酶活性。

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来源
《Journal of Medicinal Chemistry 》 |1998年第1期| 共4页
作者
Wolfe MS; Citron M; Diehl TS; Xia W; Donkor IO; Selkoe DJ;
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原文格式 PDF
正文语种 eng
中图分类药学 ;
关键词
Alzheimer Disease enzymology; Endopeptidases metabolism; Ketones; Oligopeptides; 酮类; 寡肽类; 蛋白酶抑制药;

机译：Alzheimer Disease enzymology;Endopeptidases metabolism;Ketones;Oligopeptides;酮类;寡肽类;蛋白酶抑制药;

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1. A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity. [J] . Wolfe MS, Citron M, Diehl TS, Journal of Medicinal Chemistry . 1998 ,第1期

机译：基于底物的二氟酮选择性抑制阿尔茨海默氏病的γ-分泌酶活性。
2. Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design. [J] . Moore CL, Leatherwood DD, Diehl TS, Journal of Medicinal Chemistry . 2000 ,第18期

机译：二氟酮类肽模拟物提示阿尔茨海默氏病的γ-分泌酶有较大的S1口袋：这对抑制剂设计具有重要意义。
3. 3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity. [J] . Jelley RA, Elliott J, Gibson KR, Bioorganic and Medicinal Chemistry Letters . 2006 ,第14期

机译：3-取代的基于宝石-环己烷砜的γ-分泌酶抑制剂，用于阿尔茨海默氏病：构象分析和生物学活性。
4. Dose-dependent Proteomic Analysis of Glioblastoma Cancer Stem Cells upon Treatment with Gamma-Secretase Inhibitor [C] . Lan Dai, Yashu Liu, Jaeman Byun, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：用γ-分泌酶抑制剂治疗胶质母细胞瘤癌症干细胞的剂量依赖性蛋白质组学分析
5. NG-nitro-L-arginine-containing peptidomimetics as selective neuronal nitric oxide synthase inhibitors. Structure-based design, synthesis, and biological evaluation and approaches toward enhanced CNS activity. [D] . Seo, Jiwon. 2006

机译：含NG-硝基-L-精氨酸的拟肽作为选择性神经元一氧化氮合酶抑制剂。基于结构的设计，合成和生物学评估以及增强CNS活性的方法。
6. Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimers disease [O] . Guriqbal S Basi, Susanna Hemphill, Elizabeth F Brigham, 2010

机译：淀粉样蛋白前体蛋白选择性γ-分泌酶抑制剂用于治疗阿尔茨海默氏病
7. Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease [O] . Guriqbal S Basi, Susanna Hemphill, Elizabeth F Brigham, 2011

机译：淀粉样蛋白前体蛋白选择性γ-分泌酶抑制剂用于治疗阿尔茨海默氏病

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

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