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首页> 外文期刊>Journal of magnetic resonance imaging: JMRI >Assessment of liver function in thioacetamide-induced rat acute liver injury using an empirical mathematical model and dynamic contrast-enhanced MRI with Gd-EOB-DTPA
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Assessment of liver function in thioacetamide-induced rat acute liver injury using an empirical mathematical model and dynamic contrast-enhanced MRI with Gd-EOB-DTPA

机译：使用经验数学模型和Gd-EOB-DTPA动态对比增强MRI评估硫代乙酰胺诱发的大鼠急性肝损伤中的肝功能

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Purpose: To evaluate thioacetamide (TAA)-induced acute liver injury in rats using an empirical mathematical model (EMM) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA). Materials and Methods: Eighteen rats were divided into three groups (normal control [n = 6], TAA [140] [n = 6], and TAA [280] groups [n = 6]). The rats of the TAA (140) and TAA (280) groups were intravenously injected with 140 and 280 mg/kg body weight (BW) of TAA, respectively, while those of the normal control group were intravenously injected with the same volume of saline. DCE-MRI studies were performed using Gd-EOB-DTPA (0.025 mmol Gd/kg; 0.1 mL/kg BW) as the contrast agent 48 hours after TAA or saline injection. After the DCE-MRI study, blood was sampled and serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured. We calculated the rate of contrast uptake (α), the rate of contrast washout (β), the elimination half-life of relative enhancement (RE) (T1/2), the maximum RE (REmax), and the time to (REmax) (Tmax) from time-signal intensity curves using EMM. Results: The REmax values in the TAA (140) groups and TAA (280) groups were significantly smaller than that in the normal control group. The Tmax value in the TAA (280) group was significantly greater than that in the normal control group. The β value in the TAA (280) group was significantly smaller than those in the normal control and TAA (140) groups, whereas there were no significant differences in β among groups. The T 1/2 value in the TAA (280) group was significantly greater than those in the normal control and TAA (140) groups. The REmax, T max, β, and T1/2 values significantly correlated with AST and ALT. Conclusion: The EMM is useful for evaluating TAA-induced acute liver injury using DCE-MRI with Gd-EOB-DTPA.
机译：目的：使用经验数学模型（EMM）和动态对比增强磁共振成像（DCE-MRI）和g乙氧基苄基二亚乙基三胺五乙酸（Gd-EOB-DTPA）评估硫代乙酰胺（TAA）诱导的大鼠急性肝损伤。材料和方法：将18只大鼠分为三组（正常对照组[n = 6]，TAA [140] [n = 6]和TAA [280]组[n = 6]）。 TAA（140）和TAA（280）组的大鼠分别静脉注射140和280 mg / kg体重（BW）的TAA，而正常对照组的大鼠则静脉注射相同体积的生理盐水。在TAA或注射生理盐水后48小时，使用Gd-EOB-DTPA（0.025 mmol Gd / kg; 0.1 mL / kg BW）作为造影剂进行DCE-MRI研究。在DCE-MRI研究之后，对血液取样并测量血清天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）。我们计算了造影剂摄取率（α），造影剂洗脱率（β），相对增强消除半衰期（RE）（T1 / 2），最大RE（REmax）和达到（REmax）的时间）（Tmax）从使用EMM的时间信号强度曲线得出。结果：TAA（140）组和TAA（280）组的REmax值均显着低于正常对照组。 TAA（280）组的Tmax值显着高于正常对照组。 TAA（280）组的β值显着小于正常对照组和TAA（140）组的β值，而各组之间的β值无显着差异。 TAA（280）组的T 1/2值明显高于正常对照组和TAA（140）组的T 1/2值。 REmax，Tmax，β和T1 / 2值与AST和ALT显着相关。结论：EMM可通过DCE-MRI和Gd-EOB-DTPA评估TAA诱发的急性肝损伤。

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