GET-SERF, a new gradient encoded SERF experiment for the trivial edition of ~1H-~(19)F couplings

摘要

A new spatially encoded heteronuclear ~1H-~(19)F selective refocusing NMR experiment (GET-SERF) is proposed. This sequence allows editing in one single 2D experiment all couplings between a selected fluorine site and all the proton nuclei of the molecule. Its efficiency is illustrated in the case of diflunisal, a difluorinated anti-inflammatory drug, in isotropic and anisotropic media.