Microbial Transformation of a Monoterpene, Geraniol, by the Marine-derived Fungus Hypocrea sp.

摘要

Geraniol (1) is the biogenetic precursor of a numberof monoterpenes. We tested various marine-derivedmicroorganisms to determine their ability to biotransform 1.Only Hypocrea sp. was capable of transforming 1 into itsoxidized derivative, 1,7-dihydroxy-3,7-dimethyl-(E)-oct-2-ene (2). The structure of the metabolite obtained wasassigned on the basis of detailed spectroscopic data analyses.