The Fatty Acid-Bile Acid Conjugate Aramchol Reduces Liver Fat Content in Patients With Nonalcoholic Fatty Liver Disease

Safadi Rifaat; Konikoff Fred M.; Mahamid Mahmud; Zelber-Sagi Shira; Halpern Maya; Gilat Tuvia; Oren Ran

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The Fatty Acid-Bile Acid Conjugate Aramchol Reduces Liver Fat Content in Patients With Nonalcoholic Fatty Liver Disease

机译：脂肪酸-胆汁酸共轭芳烃降低非酒精性脂肪性肝病患者的肝脂肪含量

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BACKGROUND & AIMS: We investigated the effects of the fatty acid-bile acid conjugate 3 beta-arachidyl-amido, 7 alpha-12 alpha-dihydroxy, 5 beta-cholan-24-oic acid (Aramchol; Trima Israel Pharmaceutical Products Ltd, Maabarot, Israel) in a phase 2 trial of patients with nonalcoholic fatty liver disease (NAFLD).

机译：背景与目的：我们研究了脂肪酸-胆汁酸共轭物3β-花生四基-酰胺基，7α-12α-二羟基，5β-胆碱-24-oo酸（Aramchol; Trima Israel Pharmaceutical Products Ltd，Maabarot （以色列）在一项非酒精性脂肪肝疾病（NAFLD）患者的2期试验中。

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《Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association》 |2014年第12期|共7页
作者
Safadi Rifaat; Konikoff Fred M.; Mahamid Mahmud; Zelber-Sagi Shira; Halpern Maya; Gilat Tuvia; Oren Ran;
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正文语种 eng
中图分类消化系及腹部疾病;
关键词
Clinical Trial; Lipid; Steatosis; Cholic Acid; NASH;

机译：临床试验;脂质;脂肪变性;叶酸;NASH;

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1. The Fatty Acid-Bile Acid Conjugate Aramchol Reduces Liver Fat Content in Patients With Nonalcoholic Fatty Liver Disease [J] . Safadi Rifaat, Konikoff Fred M., Mahamid Mahmud, Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association . 2014,第12期

机译：脂肪酸-胆汁酸共轭芳烃降低非酒精性脂肪性肝病患者的肝脂肪含量
2. Treatment of preestablished diet-induced fatty liver by oral fatty acid-bile acid conjugates in rodents. [J] . Leikin-Frenkel A, Goldiner I, Leikin-Gobbi D, European journal of gastroenterology and hepatology . 2008,第12期

机译：通过在啮齿动物中口服脂肪酸-胆汁酸结合物治疗预先建立的饮食诱导的脂肪肝。
3. Short-term multidisciplinary non-pharmacological intervention is effective in reducing liver fat content assessed non-invasively in patients with nonalcoholic fatty liver disease (NAFLD) [J] . ScaglioniF., MarinoM., CicciaS., Clinics and research in hepatology and gastroenterology . 2013,第4期

机译：短期多学科非药物干预可有效降低非酒精性脂肪肝疾病（NAFLD）患者的非侵入性评估肝脂肪含量
4. Hepatic Fatty Acid Profile In Mice with Nonalcoholic Fatty Liver Disease Using Magnetic Resonance Spectroscopy [C] . Aline Xavier, Flavia Zacconi, Daniel Cabrera Brazilian Congress on Biomedical Engineering . 2019

机译：使用磁共振光谱法具有非酒精性脂肪肝疾病的小鼠肝脂肪酸谱
5. Sources of fatty acids in hepatic and lipoprotein triacylglycerol: Studies in transgenic mice, and in humans with nonalcoholic fatty liver disease. [D] . Peterson, Kerry Donnelly. 2005

机译：肝和脂蛋白三酰甘油中的脂肪酸来源：转基因小鼠和非酒精性脂肪肝患者的研究。
6. Potential for Dietary ω-3 Fatty Acids to Prevent Nonalcoholic Fatty Liver Disease and Reduce the Risk of Primary Liver Cancer [O] . Donald B Jump, Christopher M Depner, Sasmita Tripathy, 2015

机译：膳食ω-3脂肪酸预防非酒精性脂肪肝并降低原发性肝癌风险的潜力
7. The Fatty Acid–Bile Acid Conjugate Aramchol Reduces Liver Fat Content in Patients With Nonalcoholic Fatty Liver Disease [O] . Safadi Rifaat, Konikoff Fred M., Mahamid Mahmud, 2014

机译：脂肪酸-胆汁酸共轭芳烃降低非酒精性脂肪性肝病患者的肝脂肪含量

The Fatty Acid-Bile Acid Conjugate Aramchol Reduces Liver Fat Content in Patients With Nonalcoholic Fatty Liver Disease

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