Are soluble ST2 levels in the picogram or nanogram range in serum of healthy subjects/disease patients?

摘要

I would like to give my comments on recently published article titled 'Serum Level of Interleukin-33 and Soluble ST2 and Their Association with Disease Activity in Patients with Behcet's Disease.' In this article authors had looked for sST2 in serum and found its level in pico-gram range (23.56 +-3.25 pg/mL and 99.01 +- 15.92 pg/mL in control and disease patients respectively), however, previous published report indicates the level of sST2 in nano-gram range (1-3). Since, sST2 represents a promising biomarker in different diseases, it is necessary to clarify this discrepancy.