A4~18F]FLUOROETHYLPIPERIDIN-4-YLMETHYL ACETATE, A ~18F-LABELLED PROBE ANALOGOUS WITH [~11C]MP4A FOR MEASURING CEREBRAL ACETYLCHOLINESTERASE ACTIVITY

摘要

Decrease of acetylcholinesterase (AChE) activity is known to occur in the brain of patients with Alzheimer's disease compared with age-matched controls. For quantitative measurement of brain AChE activity using positron emission tomography (PET), lipophilic acetylcholine analogs, N-[~11C]methylpiperidin-4-yl acetate ([~11CJMP4A) and propionate ([~11C]MP4P) were developed and applied to PET studies of dementia disorders.~18F-labelled analogues of MP4A and MP4P would have advantages such as possibility of long-distance transportation to other PET institutions, due to the longer half-life (~18F, 110 min; ~11C, 20 min) of ~18F compared to ~11C.