An efficient synthesis of (D_6)leucocrystal violet

摘要

This report presents an efficient synthesis of [D_6]leucocrystal violet. Esterification of p-toluenesulphonyl chloride with [D_4]methanol provided [D_3]methyl p-toluenesulphonate, which was used to methylate aniline to give [D_6]N,N-dimethylaniline. Condensation of [D_6]N,N-dimethylaniline with bis[4-(dimethylamino)phenyl]methanol afforded [D_6]leuco-crystal violet in an overall yield of 30% in three steps.