Why hypotheses informed by observation are often wrong: results of randomized controlled trials challenge chronic disease management strategies based on epidemiological evidence.

摘要

On the day of the announcement of the ACCORD blood pressure study results on March 14, 2010, presenters at an American College of Cardiology scientific session shared startling preliminary findings from a retrospective observational analysis of data from the International Verapamil SR-Trandolapril (INVEST) study of treatment with an angiotensin-converting enzyme (ACE) inhibitor and/or diuretic plus either a calcium channel blocker or beta-blocker for patients with hypertension and coronary artery disease.