Radioiodinated acebutolol as a new highly selective radiotracer for myocardial perfusion imaging

摘要

Acebutolol was successfully labeled with I-125 via direct electrophilic substitution reaction. Radioiodinated acebutolol was prepared with a maximum radiochemical yield of 96.5 +/- 0.3% and in vitro stability up to 72h. The in vivo biological distribution of radioiodinated acebutolol showed high heart uptake of 37.8 +/- 0.14% injected activity/g organ with low lungs and liver uptakes at 5min post-injection. In vivo receptor blocking study was carried out in mice to evaluate its selectivity to heart. Radioiodinated acebutolol showed fast heart accumulation with high heart/liver ratio, which provides the ability for fast myocardial imaging with significant decrease in the radiation hazards risk on patients. So, radioiodinated acebutolol could be displayed as a radiotracer drug of choice in case of emergency patients for myocardial perfusion imaging.