Synthesis of [3α-3H] 17α-Hydroxy pregnenolone and [3α-3H] Pregnenolone

Tian Yuan; Hong Yang; Bonacorsi Samuel J.; Balog Aaron; Gong Sharon

首页> 外文期刊>Journal of Labelled Compounds and Radiopharmaceuticals >Synthesis of [3α-3H] 17α-Hydroxy pregnenolone and [3α-3H] Pregnenolone

【24h】

Synthesis of [3α-3H] 17α-Hydroxy pregnenolone and [3α-3H] Pregnenolone

机译：[3α-3H]17α-羟基孕烯醇酮的合成

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

For the first time, [3α-3H] 17α-hydroxy pregnenolone (1) was synthesized through a multiple step sequence. The presence of [3β-3H] isomer in RP-HPLC purified product was identified by tritium NMR. The [3β-3H] isomer was then separated from [3α-3H] 17α-hydroxy pregnenolone with chiralPAK AD-H column. [3α-3H] pregnenolone (2) was synthesized from commercial available 5-pregnen-3,20-dione in one step with an improved procedure.

机译：首次通过多步合成[3α-3H]17α-羟基孕烯醇酮（1）。通过tri NMR鉴定RP-HPLC纯化产物中[3β-3H]异构体的存在。然后用chiralPAK AD-H柱从[3α-3H]17α-羟基孕烯醇酮中分离[3β-3H]异构体。 [3α-3H]孕烯醇酮（2）是由市售的5-pregnen-3,20-dione一步改进合成的。

著录项

来源
《Journal of Labelled Compounds and Radiopharmaceuticals》 |2014年第1期|共11页
作者
Tian Yuan; Hong Yang; Bonacorsi Samuel J.; Balog Aaron; Gong Sharon;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词
tritium; 17α-hydroxy pregnenolone; pregnenolone; isomer; tritium-NMR (T-NMR); chiralPAK AD-H column;

机译：17α-羟基孕烯醇酮;孕烯醇酮;异构体;tri-NMR（T-NMR）;手性PAK AD-H柱;

相似文献

外文文献
中文文献
专利

1. Synthesis of [3α-3H] 17α-Hydroxy pregnenolone and [3α-3H] Pregnenolone [J] . Tian Yuan, Hong Yang, Bonacorsi Samuel J., Journal of Labelled Compounds and Radiopharmaceuticals . 2014,第1期

机译：[3α-3H]17α-羟基孕烯醇酮的合成
2. Synthesis of pyrimidine annelated heterocycles [1]. Regioselective heterocyclization of 6-cyclopent-2-enyl-5-hydroxy-1,3-dimethyl-pyrimidine-2,4(1H,3H)-dione and 5-cyclopent-2-enyl-6-hydroxy-1,3-dimethylpyrimidine-2,4(1H,3H)-dione [J] . Krishna C.Majumdar, Uday K.Kundu, Swapan K.Samanta, Monatshefte fur Chemie . 2003,第8期

机译：嘧啶退火杂环的合成[1]。 6-环戊-2-烯基-5-羟基-1,3-二甲基-嘧啶-2,4（1H，3H）-二酮和5-环戊-2-烯基-6-羟基-1,3-的区域选择性杂环化二甲基嘧啶-2,4（1H，3H）-二酮
3. Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7α-hydroxy dehydroepiandrosterone and 7α-hydroxy pregnenolone [J] . Ken A. Rose, Genevieve Stapleton, Karin Dott Proceedings of the National Academy of Sciences of the United States of America . 1997,第10期

机译：Cyp7b是一种新型的大脑细胞色素P450，可催化神经甾体7α-羟基脱氢表雄酮和7α-羟基孕烯醇酮的合成
4. THE NITRATION PECULIARITY OF 6-HYDROXY-2-METYLPYRIMIDINE-4(3H)-ONE TO 6-HYDROXY-2-METYL-5-NITROPYRIMIDINE-4(3H)-ONE [C] . A. A. Kushtaev, N. V. Yudin, V. L. Zbarsky Seminar on new trends in research of energetic materials;NTREM '09 . 2009

机译：6-羟基-2-甲基嘧啶-4（3H）-1到6-羟基-2-甲基-5-5-硝基嘧啶-4（3H）-一个的硝化特性
5. Synthetic studies of 2-acetoxyfuran and 2(3H)-furanone as pronucleophiles in the asymmetric synthesis of butenolides. [D] . Howard, Stephen James. 2010

机译：2-丁氧基呋喃和2（3H）-呋喃酮作为亲核试剂在丁烯内酯的不对称合成中的合成研究。
6. Cyp7b a novel brain cytochrome P450 catalyzes the synthesis of neurosteroids 7α-hydroxy dehydroepiandrosterone and 7α-hydroxy pregnenolone [O] . Ken A. Rose, Genevieve Stapleton, Karin Dott, 1997

机译：Cyp7b是一种新型的大脑细胞色素P450它催化神经甾体7α-羟基脱氢表雄酮和7α-羟基孕烯醇酮的合成
7. Relationship between symptom severity and steroid variation in women with premenstrual syndrome: study on serum pregnenolone, pregnenolone sulfate, 5 alpha-pregnane-3,20-dione and 3 alpha-hydroxy-5 alpha-pregnan-20-one. [O] . M Wang, L Seippel, R H Purdy, 1996

机译：症状严重程度与妇女患有过早综合征的女性的关系：血清孕烯醇酮类，孕烯醇酮，5α-孕酮-3,20-二酮和3α-羟基-5α-妊娠-20-one的研究。
8. Results of an Acute Oral Toxicity Study in Rats with a Proprietary Mixture Containing Urea, N'-(3,4-Dichloropheny1) -N,N-Dimethyl (61%) 1,3,5-Triazine-2,4(1 H, 3H)-Dione, 3-Cyclohexyl-6-(Dimethey lamino)-1-Methyl-(17%). [R] . 2010

机译：含有尿素，N' - （3,4-二氯苯基）-N，N-二甲基（61％）1,3,5-三嗪-2,4（1 H）的专利混合物对大鼠进行急性口服毒性研究的结果3H） - 二酮，3-环己基-6-（二甲基氨基）-1-甲基 - （17％）。

Synthesis of [3α-3H] 17α-Hydroxy pregnenolone and [3α-3H] Pregnenolone

摘要

著录项

相似文献

相关主题

期刊订阅